An indirubin derivative, E804, exhibits potent angiosuppressive activity.

Abstract

Angiogenesis, the development of neovessels from pre-existing vessels, is obligatory for solid tumors survival, growth, invasion, and metastasis. Many anti-angiogenic agents are small molecules originated from natural sources. Recently, angiosuppressive effects of indirubin and its derivatives, the active components in indigo-producing herbs, have been… (More)
DOI: 10.1016/j.bcp.2011.12.003

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