An indirect optimization method for biochemical systems: description of method and application to the maximization of the rate of ethanol, glycerol, and carbohydrate production in Saccharomyces cerevisiae.

@article{Torres1997AnIO,
  title={An indirect optimization method for biochemical systems: description of method and application to the maximization of the rate of ethanol, glycerol, and carbohydrate production in Saccharomyces cerevisiae.},
  author={N{\'e}stor V. Torres and Eberhard O. Voit and C Glez-Alc{\'o}n and F. Rodriguez},
  journal={Biotechnology and bioengineering},
  year={1997},
  volume={55 5},
  pages={758-72}
}
Three metabolic models for the production of ethanol, glycerol, and carbohydrates in yeast are optimized with respect to different production rates. While originally nonlinear, all three optimization problems are reduced in such a way that methods of linear programming can be used. The optimizations lead to profiles of enzyme activities that are compatible with the physiology of the cells, which guarantees their viability and fitness, and yield higher rates of the desired final end products… CONTINUE READING
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