An indicator gene to demonstrate intracellular transposition of defective retroviruses.

@article{Heidmann1988AnIG,
  title={An indicator gene to demonstrate intracellular transposition of defective retroviruses.},
  author={T. Heidmann and Odile Heidmann and Jean François Nicolas},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 7},
  pages={2219-23}
}
An indicator gene for detection and quantitation of RNA-mediated transposition was constructed (neoRT). It was inserted into a Moloney murine leukemia provirus (Mo-MLV) deleted for the envelope gene to test for intracellular transposition of defective retroviruses [Mo-MLV(neo)RT]. NeoRT contains the selectable neo gene (which confers resistance to the drug G418), inactivated by a polyadenylylation sequence inserted between the neo promotor and coding sequence. The polyadenylylation sequence is… CONTINUE READING
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