An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans.

@article{Bonassi2007AnIM,
  title={An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans.},
  author={Stefano Bonassi and Ariana Znaor and Marcello Ceppi and Cecilia Lando and Wushou Peter Chang and Nina Holland and Micheline Kirsch-Volders and Errol Zeiger and Sadayuki Ban and Roberto Barale and Maria Paola Bigatti and Claudia Bolognesi and Antonina Cebulska-Wasilewska and Eleon{\'o}ra Fabi{\'a}nov{\'a} and Alexandra Fucic and Lars Hagmar and Gordana Joksiċ and Antonietta Martelli and Lucia Migliore and Ekaterina Mirkova and Maria Rosaria Scarfi and Andrea Zijno and Hannu Norppa and Michael Fenech},
  journal={Carcinogenesis},
  year={2007},
  volume={28 3},
  pages={625-31}
}
The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker of chromosomal damage and genome stability in human populations. Much theoretical evidence has been accumulated supporting the causal role of MN induction in cancer development, although prospective cohort studies are needed to validate MN as a cancer risk biomarker. A total of 6718 subjects from of 10 countries, screened in 20 laboratories for MN frequency between 1980 and 2002 in ad hoc… CONTINUE READING
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