An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans.

@article{Bonassi2007AnIM,
  title={An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans.},
  author={S. Bonassi and A. Znaor and M. Ceppi and C. Lando and W. Chang and N. Holland and M. Kirsch‐Volders and E. Zeiger and S. Ban and R. Barale and M. P. Bigatti and C. Bolognesi and A. Cebulska-Wasilewska and E. Fabianova and A. Fucic and L. Hagmar and G. Joksiċ and A. Martelli and L. Migliore and E. Mirkova and M. Scarf{\`i} and A. Zijno and H. Norppa and M. Fenech},
  journal={Carcinogenesis},
  year={2007},
  volume={28 3},
  pages={
          625-31
        }
}
The frequency of micronuclei (MN) in peripheral blood lymphocytes (PBL) is extensively used as a biomarker of chromosomal damage and genome stability in human populations. Much theoretical evidence has been accumulated supporting the causal role of MN induction in cancer development, although prospective cohort studies are needed to validate MN as a cancer risk biomarker. A total of 6718 subjects from of 10 countries, screened in 20 laboratories for MN frequency between 1980 and 2002 in ad hoc… Expand
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