An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression.

@article{Kang2014AnIL,
  title={An increased level of IL-6 suppresses NK cell activity in peritoneal fluid of patients with endometriosis via regulation of SHP-2 expression.},
  author={Young-Ju Kang and In Cheul Jeung and Arum Park and Young-Jun Park and Haiyoung Jung and Tae-don Kim and Hee Gu Lee and Inpyo Choi and Suk Ran Yoon},
  journal={Human reproduction},
  year={2014},
  volume={29 10},
  pages={2176-89}
}
STUDY QUESTION Is the decreased natural killer (NK) cell cytolytic activity in the peritoneal fluid (PF) of endometriosis patients due to primary cytokine activity? SUMMARY ANSWER An increased level of interleukin-6 (IL-6) in the PF of patients with endometriosis suppresses NK cell cytolytic activity by down-regulating cytolytic granule components, such as granzyme B and perforin, through the modulation of Src homology region 2-containing protein tyrosine phosphatase-2 (SHP-2) expression… CONTINUE READING