An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia.

@article{Johansen2011AnIB,
  title={An increased burden of common and rare lipid-associated risk alleles contributes to the phenotypic spectrum of hypertriglyceridemia.},
  author={Christopher Johansen and Jian Wang and Matthew B. Lanktree and Adam D Mcintyre and Matthew R. Ban and Rebecca A Martins and Brooke A. Kennedy and Reina G Hassell and Maartje Visser and Stephen M Schwartz and Benjamin F. Voight and Roberto Elos{\'u}a and Veikko V Salomaa and Christopher J. O'Donnell and Geesje M. Dallinga-Thie and Sonia Savitri Anand and Salim Yusuf and Murray W. Huff and Sekar Kathiresan and Henian Cao and Robert A Hegele},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2011},
  volume={31 8},
  pages={1916-26}
}
OBJECTIVE Earlier studies have suggested that a common genetic architecture underlies the clinically heterogeneous polygenic Fredrickson hyperlipoproteinemia (HLP) phenotypes defined by hypertriglyceridemia (HTG). Here, we comprehensively analyzed 504 HLP-HTG patients and 1213 normotriglyceridemic controls and confirmed that a spectrum of common and rare lipid-associated variants underlies this heterogeneity. METHODS AND RESULTS First, we demonstrated that genetic determinants of plasma… CONTINUE READING