An increase in nitric oxide produced by rat peritoneal neutrophils is not involved in cell apoptosis

@article{Fierro1995AnII,
  title={An increase in nitric oxide produced by rat peritoneal neutrophils is not involved in cell apoptosis},
  author={Iolanda Margherita Fierro and Christina Barja-Fidalgo and Ricardo Melgoza Ca{\~n}edo and Fernando Q Cunha and S{\'e}rgio Henrique Ferreira},
  journal={Mediators of Inflammation},
  year={1995},
  volume={4},
  pages={222 - 228}
}
Polymorphonuclear neutrophils (PMN) obtained from carrageenin-stimulated peritoneal cavities of rats, but not blood PMN, spontaneously produced nitric oxide (NO) when incubated in vitro. Incubation of the cells with the NO synthase inhibitors, L-imino-ethyl-L-ornithine (L-NIO) or N(G)-monomethyl-L-arginine (L-NMMA), inhibited NO production. This inhibition could be reversed by L-arginine. Incubation of PMN with lipopolysaccharide (LPS) failed to enhance NO production. Pretreatment of the rats… CONTINUE READING

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