An increase in lactate output by brain tissue serves to meet the energy needs of glutamate-activated neurons.

@article{Schurr1999AnII,
  title={An increase in lactate output by brain tissue serves to meet the energy needs of glutamate-activated neurons.},
  author={Avital Schurr and James Jason Miller and Ralphiel S. Payne and B. M. Rigor},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1999},
  volume={19 1},
  pages={34-9}
}
Aerobic energy metabolism uses glucose and oxygen to produce all the energy needs of the brain. Several studies published over the last 13 years challenged the assumption that the activated brain increases its oxidative glucose metabolism to meet the increased energy demands. Neuronal function in rat hippocampal slices supplied with 4 mM glucose could tolerate a 15 min activation by a 5 mM concentration of the excitatory neurotransmitter glutamate (Glu), whereas slices supplied with 10 mM… CONTINUE READING

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Brain energy metabolism: an integrated cellular perspective

  • PJ Magistretti, L Pellerin, JL Martin
  • Kupfer DJ,
  • 1995
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