An increase in cell number at completion of therapy may develop as an indicator of early relapse

@article{Pachmann2007AnII,
  title={An increase in cell number at completion of therapy may develop as an indicator of early relapse},
  author={Katharina Pachmann and Robert Dengler and Kurt Lobodasch and Frank Fr{\"o}hlich and Torsten Kroll and Matthias Rengsberger and Rene Schubert and Ulrich A. Pachmann},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2007},
  volume={134},
  pages={59-65}
}
PurposeTreatment efficiency of adjuvant therapy in breast cancer is only revealed after several years by statistical evaluation and gives no answer for the individual patient. We here present a method to analyze the response to adjuvant chemotherapy online in individual patients.Methods/resultsIn 25 consecutive non-metastatic primary breast cancer patients adjuvant fluorouracil/epirubicin/cyclophosphamid (FEC) or EC followed by taxane (EC-T) or cyclophosphamid/methotrexate/fluorouracil (CMF… 
Monitoring the response of circulating epithelial tumor cells to adjuvant chemotherapy in breast cancer allows detection of patients at risk of early relapse.
  • K. Pachmann, O. Camara, K. Höffken
  • Medicine, Biology
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2008
TLDR
The results show that peripherally circulating tumor cells are influenced by systemic chemotherapy and that an increase (even after initial response to therapy) of 10-fold or more at the end of therapy is a strong predictor of relapse and a surrogate marker for the aggressiveness of the tumor cells.
The role of circulating tumor cells in breast cancer diagnosis and prediction of therapy response.
TLDR
Standardization of methods will allow for the uniform detection of microscopic disease in the peripheral blood of patients with MBC and provide prognostic information that will allow appropriate risk stratification and modification of the current staging system for advanced disease.
Review: Biological relevance of disseminated tumor cells in cancer patients
TLDR
This review will focus on bone marrow (BM) as the main tumor entities in Europe and the United States and present currently available methods for the detection and characterization of disseminated tumor cells (DTC).
Circulating epithelial tumor cells as a prognostic tool for malignant melanoma
TLDR
Quantification of CETCs could prove to be a prognostic marker for patients with melanoma receiving interferon immunotherapy and whether these results are applicable to other immunotherapies, for example, immune checkpoint inhibition.
Circulating Tumor Cells: Detection Methods and Potential Clinical Application in Breast Cancer
TLDR
A paradigm shift may be introduced in the treatment strategy, from the present one that is based only on primary tumor characteristics to the future one that considers molecular characterization of CTCs as well.
Clinical significance of circulating tumor cells in breast cancer patients
TLDR
The results suggested that CTC assessment could be an indication of the disease progression and analysis of the properties of CTCs is likely to provide new insights into the biology of breast cancer and contribute to defining novel treatments and better prediction of clinical outcomes.
Treatment of advanced solid tumours with NSAIDs: Correlation of quantitative monitoring of circulating tumour cells and positron emission tomography-computed tomography imaging
TLDR
It may be concluded that patients with solid tumours benefit from serial quantification of CTCs in addition to imaging, as this combination of techniques provides a more sensitive result than imaging alone.
Quantification of circulating melanoma cells
TLDR
Overall, this study has identified MCAM positivity as a CTC marker associated with disease progression which may be useful in improving prognostic testing and disease management in melanoma patients.
Hormone receptor status, erbB2 expression and cancer stem cell characteristics of circulating tumor cells in breast cancer patients.
TLDR
The most important predictor for disease-free and overall survival of breast cancer patients is the presence of axillary lymph node metastasis and it appears that the CTC, and consequently the metastatic cells, may have a very different hormone and erbB2 status.
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