An increase in cell number at completion of therapy may develop as an indicator of early relapse
@article{Pachmann2007AnII, title={An increase in cell number at completion of therapy may develop as an indicator of early relapse}, author={Katharina Pachmann and Robert Dengler and Kurt Lobodasch and Frank Fr{\"o}hlich and Torsten Kroll and Matthias Rengsberger and Rene Schubert and Ulrich A. Pachmann}, journal={Journal of Cancer Research and Clinical Oncology}, year={2007}, volume={134}, pages={59-65} }
PurposeTreatment efficiency of adjuvant therapy in breast cancer is only revealed after several years by statistical evaluation and gives no answer for the individual patient. We here present a method to analyze the response to adjuvant chemotherapy online in individual patients.Methods/resultsIn 25 consecutive non-metastatic primary breast cancer patients adjuvant fluorouracil/epirubicin/cyclophosphamid (FEC) or EC followed by taxane (EC-T) or cyclophosphamid/methotrexate/fluorouracil (CMF…
32 Citations
Monitoring the response of circulating epithelial tumor cells to adjuvant chemotherapy in breast cancer allows detection of patients at risk of early relapse.
- Medicine, BiologyJournal of clinical oncology : official journal of the American Society of Clinical Oncology
- 2008
The results show that peripherally circulating tumor cells are influenced by systemic chemotherapy and that an increase (even after initial response to therapy) of 10-fold or more at the end of therapy is a strong predictor of relapse and a surrogate marker for the aggressiveness of the tumor cells.
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Review: Biological relevance of disseminated tumor cells in cancer patients
- Medicine, BiologyInternational journal of cancer
- 2008
This review will focus on bone marrow (BM) as the main tumor entities in Europe and the United States and present currently available methods for the detection and characterization of disseminated tumor cells (DTC).
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A paradigm shift may be introduced in the treatment strategy, from the present one that is based only on primary tumor characteristics to the future one that considers molecular characterization of CTCs as well.
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- MedicineBreast Cancer Research and Treatment
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It may be concluded that patients with solid tumours benefit from serial quantification of CTCs in addition to imaging, as this combination of techniques provides a more sensitive result than imaging alone.
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Overall, this study has identified MCAM positivity as a CTC marker associated with disease progression which may be useful in improving prognostic testing and disease management in melanoma patients.
Hormone receptor status, erbB2 expression and cancer stem cell characteristics of circulating tumor cells in breast cancer patients.
- Medicine, BiologyHistology and histopathology
- 2012
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