An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling

@inproceedings{Sciammas2011AnIR,
  title={An incoherent regulatory network architecture that orchestrates B cell diversification in response to antigen signaling},
  author={Roger Sciammas and Ying Li and Aryeh Warmflash and Yiqiang Song and Aaron R. Dinner and Harinder Singh},
  booktitle={Molecular systems biology},
  year={2011}
}
The B-lymphocyte lineage is a leading system for analyzing gene regulatory networks (GRNs) that orchestrate distinct cell fate transitions. Upon antigen recognition, B cells can diversify their immunoglobulin (Ig) repertoire via somatic hypermutation (SHM) and/or class switch DNA recombination (CSR) before differentiating into antibody-secreting plasma cells. We construct a mathematical model for a GRN underlying this developmental dynamic. The intensity of signaling through the Ig receptor is… CONTINUE READING