An inbred 129SvEv GFPCre transgenic mouse that deletes loxP-flanked genes in all tissues.

Abstract

A common method for generating mice with subtle genetic manipulations uses homologous recombination (HR) in embryonic stem (ES) cells to replace a wild-type gene with a slightly modified one. Generally, a drug resistance gene is inserted with the modified gene to select correctly targeted clones. Often, however, the presence of this drug resistance gene… (More)

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