An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development.

@article{Cullinane2005AnIV,
  title={An in vivo tumor model exploiting metabolic response as a biomarker for targeted drug development.},
  author={Carleen Cullinane and Donna S. Dorow and Maya Kansara and Nelly J Conus and David Binns and Rodney J Hicks and Leonie K. Ashman and Grant Mcarthur and David Thomas},
  journal={Cancer research},
  year={2005},
  volume={65 21},
  pages={9633-6}
}
In vivo models that recapitulate oncogene-dependent tumorigenesis will greatly facilitate development of molecularly targeted anticancer therapies. We have developed a model based on activating mutations in c-KIT in gastrointestinal stromal tumors (GISTs). This model comprises murine tumors of FDC-P1 cell lines expressing c-KIT mutations that render the… CONTINUE READING