An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling

@article{Orsulic1996AnIV,
  title={An in vivo structure-function study of armadillo, the beta-catenin homologue, reveals both separate and overlapping regions of the protein required for cell adhesion and for wingless signaling},
  author={Sandra Orsulic and Mark Peifer},
  journal={The Journal of Cell Biology},
  year={1996},
  volume={134},
  pages={1283 - 1300}
}
Armadillo, the Drosophila homologue of vertebrate beta-catenin, plays a pivotal role both in Wingless signaling and in assembly of adherens junctions. We performed the first in vivo structure-function study of an adherens junction protein, by generating and examining a series of Armadillo mutants in the context of the entire animal. We tested each mutant by assaying its biological function, its ability to bind proteins that normally associate with Armadillo in adherens junctions, its cellular… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 95 extracted citations

The many faces and functions of β-catenin.

The EMBO journal • 2012
View 5 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 61 references

A role for

M. Peifer, S. Orsulic, D. Sweeton, E. Wieschaus
1993
View 8 Excerpts
Highly Influenced

Assembly of the cadherin-catenin complex in vitro with recombinant proteins.

Journal of cell science • 1994
View 4 Excerpts
Highly Influenced

Phosphorylation of the Drosophila

M. Peifer, L.-M. Pal, M. Casey
1994
View 10 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…