An in vivo screen reveals protein-lipid interactions crucial for gating a mechanosensitive channel.


The bacterial mechanosensitive channel MscL is the best-studied mechanosensor, thus serving as a paradigm of how a protein senses and responds to mechanical force. Models for the transition of Escherichia coli MscL from closed to open states propose a tilting of the transmembrane domains in the plane of the membrane, suggesting dynamic protein-lipid… (More)
DOI: 10.1096/fj.10-170878


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