An in vivo orthotopic canine model to evaluate distribution of intraprostatic injectate: implications for gene therapy and drug delivery for prostate cancer.

Abstract

OBJECTIVES Complete and reliable infiltration of the entire prostate is important to improve the efficacy of intraprostatic gene therapy, as well as drug delivery. We sought to evaluate the optimal injection scheme and feasibility of magnetic resonance imaging (MRI) using a surrogate solution to assess the distribution of injectate in an orthotopic canine… (More)

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@article{Kassouf2007AnIV, title={An in vivo orthotopic canine model to evaluate distribution of intraprostatic injectate: implications for gene therapy and drug delivery for prostate cancer.}, author={Wassim Kassouf and Gordon D. A. Brown and Anil Shetty and John D. Hazle and R. Jason Stafford and Charles J Rosser and Clifton L. Stephens and Peggy T. Tinkey and Louis Pisters}, journal={Urology}, year={2007}, volume={70 4}, pages={822-5} }