An in vivo mutation from leucine to tryptophan at position 210 in human immunodeficiency virus type 1 reverse transcriptase contributes to high-level resistance to 3'-azido-3'-deoxythymidine.

@article{Hooker1996AnIV,
  title={An in vivo mutation from leucine to tryptophan at position 210 in human immunodeficiency virus type 1 reverse transcriptase contributes to high-level resistance to 3'-azido-3'-deoxythymidine.},
  author={David J. Hooker and Gilda Tachedjian and Alan Solomon and A. D. Gurusinghe and Sally Land and Chris Birch and Jenny Louise Anderson and Benjamin M. Roy and Edward Arnold and Nicholas J. Deacon},
  journal={Journal of virology},
  year={1996},
  volume={70 11},
  pages={8010-8}
}
Sequencing of the reverse transcriptase (RT) region of 26 human immunodeficiency virus type 1 (HIV-1) isolates from eight patients treated with 3'-azido-3'-deoxythymidine (AZT) revealed a mutation at codon 210 from TTG (leucine) to TGG (tryptophan) exclusively in association with resistance to AZT. The mutation Trp-210 was observed in 15 of the 20 isolates… CONTINUE READING