An in vivo mouse reporter gene (human secreted alkaline phosphatase) model to monitor ovarian tumor growth and response to therapeutics

@article{Nilsson2001AnIV,
  title={An in vivo mouse reporter gene (human secreted alkaline phosphatase) model to monitor ovarian tumor growth and response to therapeutics},
  author={Eric E Nilsson and Suzanne D. Westfall and Claudia A McDonald and Tiffany Lison and Ingrid Sadler-Riggleman and Michael K. Skinner},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2001},
  volume={49},
  pages={93-100}
}
Purpose: Developing new anticancer therapeutic regimens requires the measurement of tumor cell growth in response to treatment. This is often accomplished by injecting immunocompromised mice with cells from cancer tissue or cell lines. After treating the animals, tumor weight or volume is measured. Such methods are complicated by inaccuracies in measuring tumor mass and often animals must be killed to measure tumor burden. An in vivo tumor model system is presented in which the tumor cell line… CONTINUE READING

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New method for quantifying tumor mass in living animals. Strata- gene

  • V Zhang, P Vaillancourt, I-M Shih, B Vogelstein
  • 2000
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