An in vivo model to study the anti-malaric capacity of plant extracts.

@article{Chinchilla1998AnIV,
  title={An in vivo model to study the anti-malaric capacity of plant extracts.},
  author={Misael Chinchilla and Olga Marta Guerrero and Gabriela Heredia Abarca and M. Barrios and Oscar Castro},
  journal={Revista de biologia tropical},
  year={1998},
  volume={46 1},
  pages={
          35-9
        }
}
An in vivo model to study the antimalaric effect of plant extracts is described. White mice (25-30 g body weight) are treated subcutaneously with 0.6 ml of the diluted extract starting seven days before P. berghei infection; treatment continues until death or for 30 days. Simultaneously 0.2 ml of the extract are applied per os starting three days before infection. In a test of the model, treated and non-treated animals differed in body weight, survival time, haematocrite, parasitemia… Expand
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