An in vivo model to study osteogenic gene regulation: targeting an avian retroviral receptor (TVA) to bone with the bone sialoprotein (BSP) promoter.

@article{Li2005AnIV,
  title={An in vivo model to study osteogenic gene regulation: targeting an avian retroviral receptor (TVA) to bone with the bone sialoprotein (BSP) promoter.},
  author={Ling Li and Ji Zhu and Qisheng Tu and Masato Yamauchi and Jaro Sodek and Gerard Karsenty and Jean Tang and Jake Jinkun Chen},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2005},
  volume={20 8},
  pages={1403-13}
}
UNLABELLED To study bone development in vivo, a transgenic mouse model was established in which an avian retroviral receptor (TVA) gene driven by the BSP promoter was selectively expressed in skeletal tissues. The model was validated by showing suppressed BSP expression and delayed bone and tooth formation after infection with a virus expressing a mutated Cbfa1/Runx2 gene. INTRODUCTION Tissue-specific expression of the avian retroviral (TVA) receptor can be used to efficiently target ectopic… CONTINUE READING

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