An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

@article{Kowall1991AnIV,
  title={An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.},
  author={Neil W. Kowall and Myron Flint Beal and Jorge A. Busciglio and Lawrence K. Duffy and Bruce A. Yankner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 16},
  pages={
          7247-51
        }
}
Deposition of the beta-amyloid protein in senile plaques is a pathologic hallmark of Alzheimer disease (AD). Focal deposition of beta amyloid in the adult rat cerebral cortex caused profound neurodegenerative changes, including neuronal loss and degenerating neurons and neurites. Chronic induction of the Alz-50 antigen appeared in neurons around focal cortical deposits of beta amyloid. Immunoblot analysis showed that beta amyloid induced Alz-50-immunoreactive proteins in rat cerebral cortex… CONTINUE READING
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