An in vivo evaluation of Brilliant Blue G in animals and humans.

  title={An in vivo evaluation of Brilliant Blue G in animals and humans.},
  author={Matthias Remy and Sebastian Thaler and Ricarda G Schumann and Christian Albrecht May and Michal Fiedorowicz and Frank Schuettauf and Martin Grueterich and Siegfried Priglinger and Martin M. Nentwich and Anselm Kampik and Christos Haritoglou},
  journal={The British journal of ophthalmology},
  volume={92 8},
BACKGROUND/AIMS To evaluate the retinal toxicity of Brilliant Blue G (BBG) following intravitreal injection in rat eyes and examine the biocompatibility and the staining properties in humans. METHODS BBG was injected into the 11 rat eyes to evaluate toxic effects with balanced salt solution (BSS) serving as control. Retinal toxicity was assessed by retinal ganglion cell (RGC) counts and by light microscopy 7 days later. In addition, BBG was applied during vitrectomy for macular hole (MH) (n… CONTINUE READING
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