An in vivo control map for the eukaryotic mRNA translation machinery

@inproceedings{Firczuk2013AnIV,
  title={An in vivo control map for the eukaryotic mRNA translation machinery},
  author={Helena Firczuk and Shichina Kannambath and J{\"u}rgen Pahle and Amy Claydon and Robert J Beynon and John S. Duncan and Hans V. Westerhoff and Pedro Mendes and John G. McCarthy},
  booktitle={Molecular systems biology},
  year={2013}
}
Rate control analysis defines the in vivo control map governing yeast protein synthesis and generates an extensively parameterized digital model of the translation pathway. Among other non-intuitive outcomes, translation demonstrates a high degree of functional modularity and comprises a non-stoichiometric combination of proteins manifesting functional convergence on a shared maximal translation rate. In exponentially growing cells, polypeptide elongation (eEF1A, eEF2, and eEF3) exerts the… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 14 times over the past 90 days. VIEW TWEETS
31 Citations
58 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 58 references

Similar Papers

Loading similar papers…