An in vivo control map for the eukaryotic mRNA translation machinery

  title={An in vivo control map for the eukaryotic mRNA translation machinery},
  author={Helena Firczuk and Shichina Kannambath and J{\"u}rgen Pahle and Amy Claydon and Robert J Beynon and John S. Duncan and Hans V. Westerhoff and Pedro Mendes and John G. McCarthy},
  booktitle={Molecular systems biology},
Rate control analysis defines the in vivo control map governing yeast protein synthesis and generates an extensively parameterized digital model of the translation pathway. Among other non-intuitive outcomes, translation demonstrates a high degree of functional modularity and comprises a non-stoichiometric combination of proteins manifesting functional convergence on a shared maximal translation rate. In exponentially growing cells, polypeptide elongation (eEF1A, eEF2, and eEF3) exerts the… CONTINUE READING
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