An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects.

@article{Pagano1983AnIV,
  title={An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects.},
  author={G. Pagano and P. Cavallo-Perin and M. Cassader and A. Bruno and A. Ozzello and P. Masciola and A. Dall'omo and B. Imbimbo},
  journal={The Journal of clinical investigation},
  year={1983},
  volume={72 5},
  pages={
          1814-20
        }
}
Prednisone-induced insulin resistance may depend on either reduced sensitivity (receptor defect) or reduced response to insulin (postreceptor defect). [...] Key Method To clarify the mechanism of prednisone-induced insulin resistance, a [3H]glucose infusion (1 microCi/min) was performed for 120 min before and during a euglycemic clamp repeated at approximately 100, approximately 1,000, and approximately 10,000 microU/ml steady state plasma insulin concentration in 10 healthy, normal weight subjects, aged 35…Expand
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