An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotype.

@article{ViganWomas2008AnIV,
  title={An in vivo and in vitro model of Plasmodium falciparum rosetting and autoagglutination mediated by varO, a group A var gene encoding a frequent serotype.},
  author={Ines Vigan-Womas and Micheline Guillotte and C{\'e}cile Le Scanf and S{\'e}bastien Igonet and St{\'e}phane P{\^e}tres and Alexandre Marcel Juillerat and Cyril Badaut and Farida Nato and Achim Schneider and Aur{\'e}lien Lavergne and Hugues Contamin and Adama Tall and Laurence Baril and Graham A Bentley and Odile Mercereau-Puijalon},
  journal={Infection and immunity},
  year={2008},
  volume={76 12},
  pages={
          5565-80
        }
}
In the Saimiri sciureus monkey, erythrocytes infected with the varO antigenic variant of the Plasmodium falciparum Palo Alto 89F5 clone bind uninfected red blood cells (rosetting), form autoagglutinates, and have a high multiplication rate, three phenotypic characteristics that are associated with severe malaria in human patients. We report here that varO parasites express a var gene having the characteristics of group A var genes, and we show that the varO Duffy binding-like 1alpha(1… CONTINUE READING
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