An in vitro ultrastructural study of infectious kidney stone genesis.

@article{McLean1985AnIV,
  title={An in vitro ultrastructural study of infectious kidney stone genesis.},
  author={R J McLean and J C Nickel and Vivien Noakes and John William Costerton},
  journal={Infection and immunity},
  year={1985},
  volume={49 3},
  pages={
          805-11
        }
}
A ureolytic strain of Proteus mirabilis, isolated from a patient with infectious kidney stones, produced struvite (MgNH4PO4 X 6 H2O) and apatite [Ca10(PO4)6CO3] crystals in vitro when grown in artificial urine. Surface-attached crystals were encased in a slime-like layer. Scanning electron microscopy revealed that surfaces submerged in the artificial urine were colonized by P. mirabilis. Bacteria-associated crystals appeared soon after colonization and eventually became coated with an amorphous… CONTINUE READING

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