An in vitro network of intermolecular interactions between viral RNA segments of an avian H5N2 influenza A virus: comparison with a human H3N2 virus

@inproceedings{Gavazzi2013AnIV,
  title={An in vitro network of intermolecular interactions between viral RNA segments of an avian H5N2 influenza A virus: comparison with a human H3N2 virus},
  author={Cyrille Gavazzi and Catherine Isel and Emilie Fournier and Vincent Moules and Annie Cavalier and Daniel F Thomas and Bruno Lina and Roland Marquet},
  booktitle={Nucleic acids research},
  year={2013}
}
The genome of influenza A viruses (IAV) is split into eight viral RNAs (vRNAs) that are encapsidated as viral ribonucleoproteins. The existence of a segment-specific packaging mechanism is well established, but the molecular basis of this mechanism remains to be deciphered. Selective packaging could be mediated by direct interaction between the vRNA packaging regions, but such interactions have never been demonstrated in virions. Recently, we showed that the eight vRNAs of a human H3N2 IAV form… CONTINUE READING
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One influenza virus particle packages eight unique viral RNAs as shown by FISH analysis.

Proceedings of the National Academy of Sciences of the United States of America • 2012

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