An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: actions of TNP-470, marimastat and the tubulin-binding agent Ang-510.
@article{vanWijngaarden2010AnIV, title={An in vitro model that can distinguish between effects on angiogenesis and on established vasculature: actions of TNP-470, marimastat and the tubulin-binding agent Ang-510.}, author={Jens van Wijngaarden and Thomas J. A. Snoeks and Ermond R. van Beek and Henny Bloys and Eric L. Kaijzel and Victor W. M. van Hinsbergh and Clemens W. G. M. L{\"o}wik}, journal={Biochemical and biophysical research communications}, year={2010}, volume={391 2}, pages={ 1161-5 } }
10 Citations
Inhibitory effects of Yangzheng Xiaoji on angiogenesis and the role of the focal adhesion kinase pathway.
- Biology, MedicineInternational journal of oncology
- 2012
It was demonstrated that the focal adhesion kinase (FAK) inhibitor PF557328 had a significant synergistic effect on DME25-induced inhibition of cell adhesion, migration and tube formation, and that Yangzhen Xiaoji has a marked effect on angiogenesis, in vitro.
Preclinical Development 2-Methoxyestradiol Analogue ENMD-1198 Reduces Breast Cancer-Induced Osteolysis and Tumor Burden Both In Vitro and In Vivo
- Medicine, Biology
- 2011
ENMD-1198 showed both antiangiogenic and vascular disruptive properties and was capable of protecting the bone against tumor-induced osteolysis, and was combined with low-dose metronomic cyclophosphamide and the bisphosphonate risedronic acid, leading to a mild increase in treatment efficacy.
2-Methoxyestradiol Analogue ENMD-1198 Reduces Breast Cancer-Induced Osteolysis and Tumor Burden Both In Vitro and In Vivo
- Medicine, BiologyMolecular Cancer Therapeutics
- 2011
ENMD-1198 showed both antiangiogenic and vascular disruptive properties and was capable of protecting the bone against tumor-induced osteolysis, and was combined with low-dose metronomic cyclophosphamide and the bisphosphonate risedronic acid for a mild increase in treatment efficacy.
The Research Progress of Matrix Metalloproteinases in Invasion and Metastasis of Gastric Cancer
- Medicine
- 2015
The role of M MPs in the invasion and metastasis of gastric cancer is introduced and the drugs affected on MMPs had reached the stage of clinical trials.
Role of the Cytoskeleton in Formation and Maintenance of Angiogenic Sprouts
- BiologyJournal of Vascular Research
- 2011
Evidence for regulatory molecules and pharmacological compounds that affect actin, microtubule and intermediate filament dynamics to alter various steps of angiogenesis, including endothelial sprout formation and maintenance are discussed.
A C-terminal fragment BIGH3 protein with an RGDRGD motif inhibits corneal neovascularization in vitro and in vivo.
- BiologyExperimental eye research
- 2013
The fetal mouse metatarsal bone explant as a model of angiogenesis
- BiologyNature Protocols
- 2015
The mouse fetal metatarsal provides a unique tool for studying angiogenesis and allows the analysis of blood vessel growth, and the mechanisms underpinning this process, in a multicellular microenvironment that drives the formation of a robust and complex vascular network in the absence of exogenous growth factors.
ROL DE LAS METALOPROTEINASAS Y SUS INHIBIDORES EN PATOLOGÍA TUMORAL
- Biology
- 2012
Due to their role in cancer biology, MMPs are potential targets for future therapeutic strategies of this malignant disease.
Human Adipose Stromal Cell Angiogenesis Assay: Development of Stimulation Medium and Set-up of Cell Characterization
- Biology
- 2013
The next generation of scientists and decision-makers will have to consider whether or not to use nanofiltration membranes for the recovery of phosphorous with a second type of technology called a “silicon-like substance”.
The Research Progress of Matrix Metalloproteinases in Invasion and Metastasis of Gastric Cancer
- Biology
- 2015
The most important thing for treating gastric cancer is to prevent its invasion and metastasis, which are the most common causes of treatment failure and mortality.
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