An in vitro model of the tumor-lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion.

@article{Pisano2015AnIV,
  title={An in vitro model of the tumor-lymphatic microenvironment with simultaneous transendothelial and luminal flows reveals mechanisms of flow enhanced invasion.},
  author={Marco Pisano and Valentina Triacca and Kenneth A. Barbee and Melody A Swartz},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2015},
  volume={7 5},
  pages={525-33}
}
The most common cancers, including breast and skin, disseminate initially through the lymphatic system, yet the mechanisms by which tumor cells home towards, enter and interact with the lymphatic endothelium remain poorly understood. Transmural and luminal flows are important biophysical cues of the lymphatic microenvironment that can affect adhesion… CONTINUE READING