An in vitro model of immune complex-mediated basement membrane zone separation caused by pemphigoid antibodies, leukocytes, and complement.

@article{Gammon1982AnIV,
  title={An in vitro model of immune complex-mediated basement membrane zone separation caused by pemphigoid antibodies, leukocytes, and complement.},
  author={W R Gammon and Christopher Merritt and Daniel M Lewis and W. Mitchell Sams and Jose R Carlo and Clayton E. Wheeler},
  journal={The Journal of investigative dermatology},
  year={1982},
  volume={78 4},
  pages={285-90}
}
In this study, an in vitro model of immune complex-mediated basement membrane zone separation caused by periphigoid antibodies, serum complement, and peripheral blood leukocytes is described. When cryostat sections of fresh-frozen normal human skin were treated with either of 4 bullous pemiphigoid sera containing complement-activating anti-basement membrane zone antibodies and subsequently incubated at 37 degrees C with normal human peripheral blood leukocytes and fresh human serum, leukocytes… CONTINUE READING

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