An in-vitro model of colonisation resistance to Clostridium difficile infection.

@article{Borriello1986AnIM,
  title={An in-vitro model of colonisation resistance to Clostridium difficile infection.},
  author={S Peter Borriello and F E Barclay},
  journal={Journal of medical microbiology},
  year={1986},
  volume={21 4},
  pages={299-309}
}
To investigate the importance of the normal gut flora in preventing the establishment of Clostridium difficile in vivo we have developed an in-vitro test system based on growth in faecal emulsions. Growth of C. difficile and cytotoxin production are inhibited in faecal emulsions from healthy adults, but not in sterilised emulsions; the importance of viable bacteria in the inhibitory system is evident. Generally, faecal emulsions derived from infants, children and geriatric patients were less… CONTINUE READING

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