An in vitro model of ciprofloxacin and minocycline transport by oral epithelial cells.

@article{Brayton2002AnIV,
  title={An in vitro model of ciprofloxacin and minocycline transport by oral epithelial cells.},
  author={James J Brayton and Qing Yang and Robin J. Nakkula and John D. Walters},
  journal={Journal of periodontology},
  year={2002},
  volume={73 11},
  pages={1267-72}
}
BACKGROUND Fluoroquinolones and tetracyclines can penetrate epithelial cells, but the mechanism by which they cross the plasma membrane is unclear. In this study, a cell line derived from oral epithelium was used as a model to demonstrate a role for active transport. METHODS Transport of ciprofloxacin and minocycline by confluent cell monolayers was assayed by measuring the increase in cell-associated fluorescence. RESULTS Uptake of both agents was saturable and was inhibited at low… CONTINUE READING

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