An in vitro model for the regulation of human cytomegalovirus latency and reactivation in dendritic cells by chromatin remodelling.

@article{Reeves2005AnIV,
  title={An in vitro model for the regulation of human cytomegalovirus latency and reactivation in dendritic cells by chromatin remodelling.},
  author={Matthew B Reeves and Paul J Lehner and J. G. Sissons and John H. Sinclair},
  journal={The Journal of general virology},
  year={2005},
  volume={86 Pt 11},
  pages={
          2949-54
        }
}
Human cytomegalovirus (HCMV) is a frequent cause of major disease following primary infection or reactivation from latency in immunocompromised patients. Infection of non-permissive mononuclear cells is used for analyses of HCMV latency in vitro. Using this approach, it is shown here that repression of lytic gene expression following experimental infection of CD34+ cells, a site of HCMV latency in vivo, correlates with recruitment of repressive chromatin around the major immediate-early… CONTINUE READING

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