An in vitro model for the evaluation of the adhesion of solid oral dosage forms to the oesophagus.

@article{Smart2013AnIV,
  title={An in vitro model for the evaluation of the adhesion of solid oral dosage forms to the oesophagus.},
  author={John D. Smart and Sian Dunkley and John Tsibouklis and Simon Au Young},
  journal={International journal of pharmaceutics},
  year={2013},
  volume={447 1-2},
  pages={
          199-203
        }
}
Adhesion of solid oral dosage forms to the oesophagus can be a disadvantage when delivering drugs that may cause oesophageal damage, or can be an advantage when developing localised therapies for this region. In this study, apparatus to investigate coatings that may influence oesophageal retention was developed and evaluated. The apparatus incorporated a section of porcine oesophageal mucosa held flat by the application of a gentle vacuum and kept moist by the application of a simulated saliva… CONTINUE READING
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