An in vitro method to manipulate the direction and functional strength between neural populations

  title={An in vitro method to manipulate the direction and functional strength between neural populations},
  author={Liangbin Pan and Sankaraleengam Alagapan and Eric W. Franca and Stathis S. Leondopulos and Thomas B. DeMarse and Gregory J. Brewer and Bruce C. Wheeler},
  booktitle={Front. Neural Circuits},
We report the design and application of a Micro Electro Mechanical Systems (MEMs) device that permits investigators to create arbitrary network topologies. With this device investigators can manipulate the degree of functional connectivity among distinct neural populations by systematically altering their geometric connectivity in vitro. Each polydimethylsilxane (PDMS) device was cast from molds and consisted of two wells each containing a small neural population of dissociated rat cortical… CONTINUE READING
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