An in vitro comparison of the effects of the prooxidative riminophenazines clofazimine and B669 on neutrophil phospholipase A2 activity and superoxide generation.

@article{Krajewska1993AnIV,
  title={An in vitro comparison of the effects of the prooxidative riminophenazines clofazimine and B669 on neutrophil phospholipase A2 activity and superoxide generation.},
  author={M M Krajewska and Ronald Anderson},
  journal={The Journal of infectious diseases},
  year={1993},
  volume={167 4},
  pages={
          899-904
        }
}
  • M M Krajewska, Ronald Anderson
  • Published in
    The Journal of infectious…
    1993
  • Biology, Medicine
  • The effects of the antimycobacterial agent clofazimine and its experimental analogue B669 on the phospholipase A2 activity of and superoxide generation by human blood neutrophils were investigated in vitro. Coincubation of neutrophils with clofazimine or B669 (1-10 micrograms/mL) was accompanied by a dose-related increase in the release of both [3H]lysophosphatidylcholine (LPC) and [3H]arachidonate (AA). Both agents (1 microgram/mL) also increased the production of superoxide by resting and… CONTINUE READING

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