An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma.

@article{Wu1989AnIV,
  title={An in vitro and in vivo study of antitumor effects of gossypol on human SW-13 adrenocortical carcinoma.},
  author={Yu Wei Wu and Constance L. Chik and Richard A. Knazek},
  journal={Cancer research},
  year={1989},
  volume={49 14},
  pages={
          3754-8
        }
}
The present study investigated the in vitro and in vivo antitumor effects of gossypol on human SW-13 adrenocortical carcinoma cells. In vitro gossypol concentrations greater than or equal to 0.5 microM reduced the growth rate of the SW-13 cells. Membrane microviscosity was determined by fluorescence polarization of diphenylhexatriene. The membranes of viable SW-13 cells exposed to gossypol became more rigid after a 1-day exposure to gossypol, the polarization constant, P, increasing from 0.229… CONTINUE READING

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