An in vitro and in vivo study of a novel zinc complex, zinc N-(2-hydroxyacetophenone)glycinate to overcome multidrug resistance in cancer.

@article{Ghosh2011AnIV,
  title={An in vitro and in vivo study of a novel zinc complex, zinc N-(2-hydroxyacetophenone)glycinate to overcome multidrug resistance in cancer.},
  author={Ruma Dey Ghosh and Satyajit Das and Avishek Ganguly and Kaushik Banerjee and Paramita Chakraborty and Avijit Sarkar and Moitrayee Chatterjee and Ashis Nanda and Kiran Pradhan and Soumitra Kumar Choudhuri},
  journal={Dalton transactions},
  year={2011},
  volume={40 41},
  pages={10873-84}
}
Multiple drug resistance (MDR) remains a major clinical challenge for cancer treatment. P-glycoprotein is the major contributor and they exceed their role in the chemotherapy resistance of most of the malignancies. Attempts in several preclinical and clinical studies to reverse the MDR phenomenon by using MDR modulators have not yet generated promising results. In the present study, a co-ordination complex of zinc viz., Zn N-(2-hydroxyacetophenone)glycinate (ZnNG) has been synthesized… CONTINUE READING