An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists.

@article{Eubanks2007AnIV,
  title={An in vitro and in vivo disconnect uncovered through high-throughput identification of botulinum neurotoxin A antagonists.},
  author={Lisa M Eubanks and Mark S Hixon and Wei Jin and Sukwon Hong and Colin M Clancy and William Howard Tepp and Michael R Baldwin and Carl J. Malizio and Michael C. Goodnough and Joseph T. Barbieri and Eric Arthur Johnson and Dale L. Boger and Tobin J. Dickerson and Kim D Janda},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 8},
  pages={2602-7}
}
Among the agents classified as "Category A" by the U.S. Centers for Disease Control and Prevention, botulinum neurotoxin (BoNT) is the most toxic protein known, with microgram quantities of the protein causing severe morbidity and mortality by oral or i.v. routes. Given that this toxin easily could be used in a potential bioterrorist attack, countermeasures urgently are needed to counteract the pathophysiology of BoNT. At a molecular level, BoNT exerts its paralytic effects through… CONTINUE READING

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