An in vitro and in vivo comparison of the effect of Stevia rebaudiana extracts on different caries-related variables: a randomized controlled trial pilot study.

@article{Brambilla2014AnIV,
  title={An in vitro and in vivo comparison of the effect of Stevia rebaudiana extracts on different caries-related variables: a randomized controlled trial pilot study.},
  author={Eugenio Brambilla and Maria Grazia Cagetti and Andrei C. Ionescu and Guglielmo G Campus and Peter K Lingstr{\"o}m},
  journal={Caries research},
  year={2014},
  volume={48 1},
  pages={19-23}
}
The effect of Stevia extracts on in vitro Streptococcus mutans biofilm formation and in vivo plaque pH was evaluated in this paper. Three 10% solutions containing stevioside, rebaudioside A or sucrose were prepared. MTT assay was used to evaluate microbiological counts in vitro. Twenty volunteers rinsed for 1 min with each solutions, and plaque pH was measured at 7 time points after each rinse. Higher in vitro S. mutans biofilm formation was observed in sucrose solution (p < 0.01). After 5, 10… CONTINUE READING