An in situ quantitative immunohistochemical study of cytokines and IL-2R+ in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens.

@article{Reis1997AnIS,
  title={An in situ quantitative immunohistochemical study of cytokines and IL-2R+ in chronic human chagasic myocarditis: correlation with the presence of myocardial Trypanosoma cruzi antigens.},
  author={M M Reis and Maria de Lourdes Higuchi and Luiz Alberto Benvenuti and Vera demarchi Aiello and Paulo Sampaio Gutierrez and Giovanni Bellotti and F{\'u}lvio Pileggi},
  journal={Clinical immunology and immunopathology},
  year={1997},
  volume={83 2},
  pages={165-72}
}
Inflammatory cells positive for the cytokines IL-2, IL-4, IL-6, TNF-alpha, and IFN-gamma and for IL-2R, as well as CD8+ and CD4+ T cells and B cells were quantified using an immunoperoxidase technique in 25 fresh myocardial fragments from patients presenting with chronic chagasic cardiomyopathy. The presence of Trypanosoma cruzi antigens (Ags) in the myocardium was also investigated. The cases were grouped into group A (no Ag), group B (scarce extramyocardial fiber Ags), and group C… CONTINUE READING
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