An in situ cross-linking hybrid hydrogel for controlled release of proteins.

Abstract

There is a clear need for methods to provide a safe controlled release of therapeutic proteins, either to achieve and maintain high local protein concentrations, or for sustained systemic delivery. We have developed a protein delivery system that combines in situ cross-linkable polysaccharide hydrogels with gelatin. This formulation is injectable, easy to… (More)
DOI: 10.1016/j.actbio.2012.01.028

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