An in silico skin absorption model for fragrance materials.

@article{Shen2014AnIS,
  title={An in silico skin absorption model for fragrance materials.},
  author={Jie Shen and Lambros Kromidas and T. Wayne Schultz and Sneha Bhatia},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2014},
  volume={74},
  pages={164-76}
}
Fragrance materials are widely used in cosmetics and other consumer products. The Research Institute for Fragrance Materials (RIFM) evaluates the safety of these ingredients and skin absorption is an important parameter in refining systemic exposure. Currently, RIFM's safety assessment process assumes 100% skin absorption when experimental data are lacking. This 100% absorption default is not supportable and alternate default values were proposed. This study aims to develop and validate a… CONTINUE READING
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