An in silico analysis of T-box regulated genes and T-box evolution in prokaryotes, with emphasis on prediction of substrate specificity of transporters

@article{Wels2008AnIS,
  title={An in silico analysis of T-box regulated genes and T-box evolution in prokaryotes, with emphasis on prediction of substrate specificity of transporters},
  author={Michiel Wels and Tom Groot Kormelink and Michiel Kleerebezem and Roland J. Siezen and Christof Francke},
  journal={BMC Genomics},
  year={2008},
  volume={9},
  pages={330 - 330}
}
T-box anti-termination is an elegant and sensitive mechanism by which many bacteria maintain constant levels of amino acid-charged tRNAs. The amino acid specificity of the regulatory element is related to a so-called specifier codon and can in principle be used to guide the functional annotation of the genes controlled via the T-box anti-termination mechanism. Hidden Markov Models were defined to search the T-box regulatory element and were applied to all completed prokaryotic genomes. The vast… CONTINUE READING