An in-depth map of polyadenylation sites in cancer

  title={An in-depth map of polyadenylation sites in cancer},
  author={Yuefeng Lin and Zhihua Li and Fatih Ozsolak and Sang Woo Kim and G. A. Arango-Argoty and Teresa T. Liu and Scott A. Tenenbaum and Timothy Bailey and A. Paula Monaghan and Patrice M. Milos and Bino John},
  booktitle={Nucleic acids research},
We present a comprehensive map of over 1 million polyadenylation sites and quantify their usage in major cancers and tumor cell lines using direct RNA sequencing. We built the Expression and Polyadenylation Database to enable the visualization of the polyadenylation maps in various cancers and to facilitate the discovery of novel genes and gene isoforms that are potentially important to tumorigenesis. Analyses of polyadenylation sites indicate that a large fraction (∼30%) of mRNAs contain… CONTINUE READING
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A User's Guide to the Encyclopedia of DNA Elements (ENCODE)

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