An improved system for packaging recombinant adeno-associated virus vectors capable of in vivo transduction.

@article{Flotte1995AnIS,
  title={An improved system for packaging recombinant adeno-associated virus vectors capable of in vivo transduction.},
  author={Terence R. Flotte and X Barraza-Ortiz and Rikki Solow and Sandra A Afione and Barrie J. Carter and William B Guggino},
  journal={Gene therapy},
  year={1995},
  volume={2 1},
  pages={29-37}
}
Adeno-associated virus (AAV) vectors are potentially useful for gene therapy of a number of human diseases. However, the use of these vectors has been limited by the lack of stable vector-packaging cell lines. The difficulties in developing packaging cell lines relate to low levels of rep gene expression from the AAV-p5 promoter, and to the propensity of Rep proteins to suppress continued growth of immortalized cell lines. We describe here two new techniques which allow these problems to be… CONTINUE READING

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