An improved physico-chemical model of hybridization on high-density oligonucleotide microarrays

Abstract

MOTIVATION High-density DNA microarrays provide useful tools to analyze gene expression comprehensively. However, it is still difficult to obtain accurate expression levels from the observed microarray data because the signal intensity is affected by complicated factors involving probe-target hybridization, such as non-linear behavior of hybridization, non… (More)
DOI: 10.1093/bioinformatics/btn109

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