An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen.

@article{Temelkovski1998AnIM,
  title={An improved murine model of asthma: selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolised allergen.},
  author={Jason Temelkovski and Simon P Hogan and Darren P. Shepherd and Paul S Foster and R. V. M. S. S. Kiran Kumar},
  journal={Thorax},
  year={1998},
  volume={53 10},
  pages={849-56}
}
BACKGROUND Existing murine models of asthma lack many of the inflammatory and epithelial changes that are typical of the human disease. Moreover, these models are frequently complicated by allergic alveolitis. METHODS High IgE responder BALB/c mice were systemically sensitised to ovalbumin and chronically challenged with low particle mass concentrations of aerosolised ovalbumin. Titres of antiovalbumin IgE in serum were measured at two weekly intervals by enzyme immunoassay, accumulation of… CONTINUE READING
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