An improved murine femur fracture device for bone healing studies.

@article{Marturano2008AnIM,
  title={An improved murine femur fracture device for bone healing studies.},
  author={Joseph E. Marturano and Benjamin C Cleveland and Melissa A Byrne and Shannon L O'Connell and John J. Wixted and Kristen Billiar},
  journal={Journal of biomechanics},
  year={2008},
  volume={41 6},
  pages={1222-8}
}
Murine models are commonly used to investigate bone healing and test new treatments before human trials. Our objective was to design an improved murine femur fracture device and determine optimal mass and velocity settings for maximal likelihood of transverse fracture. Fracture reproducibility was maximized using an adjustable kinetic energy level, a novel mouse positioning system and an electromagnet striker release assembly. Sixty wild-type mice of 8-12-week-old male and female with a weight… CONTINUE READING

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