An improved mouse line for Cre-induced cell ablation due to diphtheria toxin A, expressed from the Rosa26 locus.

@article{Brockschnieder2006AnIM,
  title={An improved mouse line for Cre-induced cell ablation due to diphtheria toxin A, expressed from the Rosa26 locus.},
  author={Damian Brockschnieder and Yvonne Pechmann and Eva Sonnenberg-Riethmacher and Dieter Riethmacher},
  journal={Genesis},
  year={2006},
  volume={44 7},
  pages={322-7}
}
The means to specifically ablate cells inside of a living organism have recently been improved and facilitated by stable mouse lines, carrying conditional expression constructs for diphtheria toxin (DT) or diphtheria toxin receptor, that could be activated upon Cre-mediated recombination or the application of diphtheria toxin, respectively. We have lately described the R26:lacZ/DT-A line (Brockschnieder et al., 2004, Mol Cell Biol 24:7636-7642) in which a loxP-conditional DTA allele was… CONTINUE READING